Hydrochloric Acid → HCID 11515081, compound

Participants

Reaction Conditions

Reaction Steps

In a nitrogen atmosphere at 5° C., 1290 ml of 1.6M butyllithium in hexane was added to a mixture of 168 g of 1,1,1,3,3,3-hexafluoro-2-propanol and 1200 g of tetrahydrofuran, followed by one hour of stirring at 5° C. Then 142 g of 2-oxopropyl methacrylate was added at 5° C. The mixture was stirred for 10 hours, after which dilute hydrochloric acid was added to quench the reaction and neutralize the reaction mixture. This was followed by conventional aqueous work-up and purification by silica gel column chromatography, collecting 253 g of the product (yield 82%).

Provenance & Evidence