Back
HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 491289Generated: October 30, 2026

Methane → 1-(4-Fluorophenyl)-1H-imidazole-4-carboxylic acid

https://huagongshe.com/reaction/491289

Reaction equation

Participants

RoleNameHCIDCharge
ReactantMethaneHCID 297—
ReactantHCID 17390092HCID 17390092—
SolventSodium HydroxideHCID 14798—
Solvent1,4-DioxaneHCID 31275—
Product1-(4-Fluorophenyl)-1H-imidazole-4-carboxylic acidHCID 17390048—

Reaction Steps

Crude 1-(4-fluoro-phenyl)-1H-imidazole-4-carboxylic acid ethyl ester is dissolved in dioxane and sodium hydroxide solution. The reaction mixture is refluxed for about 2 h. Charcoal is added and reflux is continued. The desired compound 1-(4-fluoro-phenyl)-1H-imidazole-4-carboxylic acid is obtained.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07531529B2
Source datasetuspto-grants-2009_05
ORD IDord-2f1950d08472457bafd566490f9c4100
Source noteuspto-grants-2009_05