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Potassium Carbonate → 4-Ethynyl-1-(4-fluorophenyl)-2-methyl-1H-imidazole
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Potassium Carbonate | HCID 11430 | — |
| 反応物 | Phosphonic acid, dimethyl ester | HCID 13361 | — |
| 反応物 | 1-(4-fluoro-phenyl)-2-methyl-1H-imidazole-4-carbaldehyde | HCID 85997993 | — |
| 溶媒 | Methanol | HCID 887 | — |
| 生成物 | 4-Ethynyl-1-(4-fluorophenyl)-2-methyl-1H-imidazole | HCID 11665595 | — |
反応手順
Diazo-2-oxo-propyl)-phosphonic acid dimethyl ester is dissolved in methanol. Potassium carbonate is added. A solution of 1-(4-fluoro-phenyl)-2-methyl-1H-imidazole-4-carbaldehyde in methanol is added dropwise at room temperature. The reaction mixture is stirred at room temperature overnight. The desired compound 4-ethynyl-1-(4-fluoro-phenyl)-2-methyl-1H-imidazole is obtained.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07531529B2 |
| 出典データセット | uspto-grants-2009_05 |
| ORD ID | ord-5195c6c02cac429599457ba97814ce90 |
| 出典メモ | uspto-grants-2009_05 |