2-Fluoro-4-iodopyridine → 2-Fluoro-4-[1-(4-fluoro-phenyl)-2-methyl-1H-imidazol-4-ylethynyl]-pyridine

HRID 491296Notes

Reaction equation

HRID 491296 reaction equation
[C:1]([C:3]1[N:4]=[C:5]([CH3:15])[N:6]([C:8]2[CH:13]=[CH:12][C:11]([F:14])=[CH:10][CH:9]=2)[CH:7]=1)#[CH:2].[F:16][C:17]1[CH:22]=[C:21](I)[CH:20]=[CH:19][N:18]=1>>[F:16][C:17]1[CH:22]=[C:21]([C:2]#[C:1][C:3]2[N:4]=[C:5]([CH3:15])[N:6]([C:8]3[CH:13]=[CH:12][C:11]([F:14])=[CH:10][CH:9]=3)[CH:7]=2)[CH:20]=[CH:19][N:18]=1

Participants

3

Reactant 2

HCID 70235702-Fluoro-4-iodopyridineHCID 116655954-Ethynyl-1-(4-fluorophenyl)-2-methyl-1H-imidazole

Product 1

HCID 111622272-Fluoro-4-[1-(4-fluoro-phenyl)-2-methyl-1H-imidazol-4-ylethynyl]-pyridine

Procedure

The title compound, MS: m/e=296.1 (M+H+), was prepared in accordance with the general method of example 1 from 4-ethynyl-1-(4-fluoro-phenyl)-2-methyl-1H-imidazole and 2-fluoro-4-iodopyridine.

Sources & evidence

ORD record
ord-e23ef242855f4f37a2b1c6ad0e48b0ca
Source dataset
uspto-grants-2009_05
Patent number
US07531529B2

Reaction notes

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