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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 491300Generated: October 26, 2026

3,5-Difluoropyridine → 3-[4-(2-Chloro-pyridin-4-ylethynyl)-2-methyl-imidazol-1-yl]-5-fluoro-pyridine

https://huagongshe.com/reaction/491300

Reaction equation

Participants

RoleNameHCIDCharge
Reactant3,5-DifluoropyridineHCID 642820—
ReactantHCID 178418879HCID 178418879—
Product3-[4-(2-Chloro-pyridin-4-ylethynyl)-2-methyl-imidazol-1-yl]-5-fluoro-pyridineHCID 24991398—

Reaction Steps

The title compound, MS: m/e=313.1 (M+H+), was prepared in accordance with the general method of example 3 from 2-chloro-4-(2-methyl-1H-imidazol-4-ylethynyl)-pyridine and 3,5-difluoro-pyridine.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07531529B2
Source datasetuspto-grants-2009_05
ORD IDord-0f0f7697cb264ef8b0240483e5da9cd2
Source noteuspto-grants-2009_05