4-Fluorophenylboronic acid → 1-(4-fluoro-phenyl)-4-iodo-2-isopropyl-1H-imidazole

HRID 491303Notes

Reaction equation

HRID 491303 reaction equation
[I:1][C:2]1[NH:6][C:5]([CH:7]([CH3:9])[CH3:8])=[N:4][CH:3]=1.[F:10][C:11]1[CH:16]=[CH:15][C:14](B(O)O)=[CH:13][CH:12]=1>>[F:10][C:11]1[CH:16]=[CH:15][C:14]([N:4]2[CH:3]=[C:2]([I:1])[N:6]=[C:5]2[CH:7]([CH3:9])[CH3:8])=[CH:13][CH:12]=1

Participants

3

Reactant 2

HCID 2856454-Fluorophenylboronic acidHCID 121602595-iodo-2-isopropyl-1H-imidazole

Product 1

HCID 673041751-(4-fluoro-phenyl)-4-iodo-2-isopropyl-1H-imidazole

Procedure

The title compound, MS: m/e=331.1 (M+H+), was prepared in accordance with the general method of example 7 from 5-iodo-2-isopropyl-1H-imidazole and 4-fluorobenzene boronic acid.

Sources & evidence

ORD record
ord-8cf4ddfc680d48158e117921dae744d2
Source dataset
uspto-grants-2009_05
Patent number
US07531529B2

Reaction notes

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