2-Chloropyridine-5-boronic acid → 4-[1-(6-Chloro-pyridin-3-yl)-2-methyl-1H-imidazol-4-ylethynyl]-pyridine-2-carbonitrile

HRID 491325Notes

Reaction equation

HRID 491325 reaction equation
[CH3:1][C:2]1[NH:3][CH:4]=[C:5]([C:7]#[C:8][C:9]2[CH:14]=[CH:13][N:12]=[C:11]([C:15]#[N:16])[CH:10]=2)[N:6]=1.[Cl:17][C:18]1[N:23]=[CH:22][C:21](B(O)O)=[CH:20][CH:19]=1>>[Cl:17][C:18]1[N:23]=[CH:22][C:21]([N:3]2[CH:4]=[C:5]([C:7]#[C:8][C:9]3[CH:14]=[CH:13][N:12]=[C:11]([C:15]#[N:16])[CH:10]=3)[N:6]=[C:2]2[CH3:1])=[CH:20][CH:19]=1

Participants

3

Reactant 2

HCID 38450342-Chloropyridine-5-boronic acidHCID 178432714HCID 178432714, compound

Product 1

HCID 249637184-[1-(6-Chloro-pyridin-3-yl)-2-methyl-1H-imidazol-4-ylethynyl]-pyridine-2-carbonitrile

Procedure

The title compound, MS: m/e=320.0, 322.1 (M+H+), was prepared in accordance with the general method of example 7 from 4-(2-Methyl-1H-imidazol-4-ylethynyl)-pyridine-2-carbonitrile and 6-chloro-3-pyridinyl-boronic acid.

Sources & evidence

ORD record
ord-d0c9cd1f85744dac93c96543517e14ea
Source dataset
uspto-grants-2009_05
Patent number
US07531529B2

Reaction notes

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