HCID 131727441, compound → HCID 131727440, compound

HRID 491406Notes

Reaction equation

HRID 491406 reaction equation
[NH:1](C(OC(C)(C)C)=O)[C@H:2]([C:10]([OH:12])=[O:11])[CH2:3][C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=1.[NH2:20][N:21]1[CH2:27][C:25](=[O:26])[NH:24][C:22]1=[O:23]>Cl.O1CCOCC1>[NH2:1][C@H:2]([C:10]([OH:12])=[O:11])[CH2:3][C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=1.[NH2:20][N:21]1[CH2:27][C:25](=[O:26])[NH:24][C:22]1=[O:23]

Participants

3

Reactant 1

HCID 131727441HCID 131727441, compound

Product 1

HCID 131727440HCID 131727440, compound

Reagents, catalysts & solvents 1

HCID 204431481,4-Dioxane hydrochlorideSolvent

Procedure

The resulting Boc-Phe-Aminohydantoin (0.25 mmol) was dissolved in 5 ml 4M HCl/Dioxan. The solution was stirred for 2 hours at room temperature. Afterwards the solvent was removed and the residue was washed with diethyl ether. Solid product was dried in vaccuo.

Workup

  1. customAfterwards the solvent was removed
  2. washthe residue was washed with diethyl ether
  3. customSolid product was dried in vaccuo

Sources & evidence

ORD record
ord-20ef1c2a30ea4a0f92c86e07fb9e9bcc
Source dataset
uspto-grants-2009_05
Patent number
US07531517B2

Reaction notes

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