4-Chlorothieno[2,3-d]pyrimidine → HCID 10128333, compound

HRID 491446Notes

Reaction equation

HRID 491446 reaction equation
Cl[C:2]1[C:3]2[CH:10]=[CH:9][S:8][C:4]=2[N:5]=[CH:6][N:7]=1.[CH3:11][O:12][C:13]1[CH:14]=[C:15]([C:21]2[C@@H:30]3[C@@H:25]([CH2:26][CH:27]=[CH:28][CH2:29]3)[C:24](=[O:31])[N:23]([CH:32]3[CH2:37][CH2:36][N:35](C4C=CC([N+]([O-])=O)=CC=4)[CH2:34][CH2:33]3)[N:22]=2)[CH:16]=[CH:17][C:18]=1[O:19][CH3:20]>O>[CH3:11][O:12][C:13]1[CH:14]=[C:15]([C:21]2[C@@H:30]3[C@@H:25]([CH2:26][CH:27]=[CH:28][CH2:29]3)[C:24](=[O:31])[N:23]([CH:32]3[CH2:37][CH2:36][N:35]([C:2]4[C:3]5[CH:10]=[CH:9][S:8][C:4]=5[N:5]=[CH:6][N:7]=4)[CH2:34][CH2:33]3)[N:22]=2)[CH:16]=[CH:17][C:18]=1[O:19][CH3:20]

Participants

4

Reactant 2

HCID 7366184-Chlorothieno[2,3-d]pyrimidineHCID 10128150HCID 10128150, compound

Product 1

HCID 10128333HCID 10128333, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

Prepared from 4-Chloro-thieno[2,3-d]pyrimidine and starting compound A1 as described for compound 11. After the addition of water, the mixture is extracted with diethyl ether. The ether solution is dried over magnesium sulfate. After the addition of a saturated solution of hydrochloric acid in ether, the compound precipitates. M.p. 219-220° C.

Workup

  1. extractionthe mixture is extracted with diethyl ether
  2. dry with materialThe ether solution is dried over magnesium sulfate
  3. additionAfter the addition of a saturated solution of hydrochloric acid in ether
  4. customthe compound precipitates

Sources & evidence

ORD record
ord-554725be02284459a5bbfe243665e737
Source dataset
uspto-grants-2009_05
Patent number
US07531540B2

Reaction notes

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