HCID 10128150, compound → HCID 86601097, compound

HRID 491448Notes

Reaction equation

HRID 491448 reaction equation
[Cl:1][CH2:2][C:3]1[CH:12]=[C:11]2[C:6]([CH:7]=[CH:8][C:9](=[O:13])[O:10]2)=[CH:5][CH:4]=1.[CH3:14][O:15][C:16]1[CH:17]=[C:18]([C:24]2[C@@H:33]3[C@@H:28]([CH2:29][CH:30]=[CH:31][CH2:32]3)[C:27](=[O:34])[N:26]([CH:35]3[CH2:40][CH2:39][N:38](C4C=CC([N+]([O-])=O)=CC=4)[CH2:37][CH2:36]3)[N:25]=2)[CH:19]=[CH:20][C:21]=1[O:22][CH3:23]>O>[ClH:1].[CH3:14][O:15][C:16]1[CH:17]=[C:18]([C:24]2[C@@H:33]3[C@@H:28]([CH2:29][CH:30]=[CH:31][CH2:32]3)[C:27](=[O:34])[N:26]([CH:35]3[CH2:40][CH2:39][N:38]([CH2:2][C:3]4[CH:12]=[C:11]5[C:6]([CH:7]=[CH:8][C:9](=[O:13])[O:10]5)=[CH:5][CH:4]=4)[CH2:37][CH2:36]3)[N:25]=2)[CH:19]=[CH:20][C:21]=1[O:22][CH3:23]

Participants

4

Reactant 2

HCID 10128150HCID 10128150, compoundHCID 22311322HCID 22311322, compound

Product 1

HCID 86601097HCID 86601097, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

Prepared from 7-Chloromethyl-chromen-2-one and starting compound A1 as described for compound 11. After the addition of water, the mixture is extracted with diethyl ether. The ether solution is dried over magnesium sulfate. After the addition of a saturated solution of hydrochloric acid in ether, the compound precipitates. M.p. 264-267° C.

Workup

  1. extractionthe mixture is extracted with diethyl ether
  2. dry with materialThe ether solution is dried over magnesium sulfate
  3. additionAfter the addition of a saturated solution of hydrochloric acid in ether
  4. customthe compound precipitates

Sources & evidence

ORD record
ord-5594a3374d6147d8bf3f5895caa2beb5
Source dataset
uspto-grants-2009_05
Patent number
US07531540B2

Reaction notes

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