4-Ethyl-2,3-dioxopiperazinecarbonyl chloride → 1-(1-{4-[(4aS,8aR)-4-(3,4-Dimethoxyphenyl)-1-oxo4a,5,8,8a-tetrahydro-1H-phthalazin-2-yl]-piperidin-1-yl}-methanoyl)-4-ethyl-piperazine-2,3-dione

Participants

Role	Name	HCID	Charge
Reactant	4-Ethyl-2,3-dioxopiperazinecarbonyl chloride	HCID 108813	—
Reactant	(4aS,8aR)-4-(3,4-Diethoxyphenyl)-2-[1-(toluene-4-sulfonyl)-piperidin-4-yl]-4a,5,8,8a-tetrahydro-2H-phthalazin-1-one	HCID 10175016	—
Product	1-(1-{4-[(4aS,8aR)-4-(3,4-Dimethoxyphenyl)-1-oxo4a,5,8,8a-tetrahydro-1H-phthalazin-2-yl]-piperidin-1-yl}-methanoyl)-4-ethyl-piperazine-2,3-dione	HCID 9828642	—

Reaction Steps

Prepared from 4-ethyl-2,3-dioxo-piperazine-1-carbonyl chloride and starting compound A1 as described for compound 1. Crystallisation from ethyl acetate/diethyl ether. M.p. 226-228° C.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US07531540B2
Source dataset	uspto-grants-2009_05
ORD ID	ord-56da14b202404792b32d8c6cf0e2376e
Source note	uspto-grants-2009_05