HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triethylamine → (4aS,8aR)-4-(3,4-Dimethoxy-phenyl)-2-piperidin-4-yl-4a,5,8,8a-tetrahydro-2H-phthalazin-1-one hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | 1-Phenethylamine, (-)- | HCID 75818 | — |
| Reactant | cis-2-(3,4-Dimethoxybenzoyl)-1,2,3,6-tetrahydrobenzoic acid | HCID 11087524 | — |
| Reactant | 2,6-Dichloro-3-fluoroacetophenone | HCID 22311317 | — |
| Solvent | 1-Propanol | HCID 1031 | — |
| Product | (4aS,8aR)-4-(3,4-Dimethoxy-phenyl)-2-piperidin-4-yl-4a,5,8,8a-tetrahydro-2H-phthalazin-1-one hydrochloride | HCID 68878851 | — |
Reaction Steps
A solution of 50 mmol of the salt of (S)-(−)-α-methylbenzylamine and (cis)-2-(3,4-dimethoxybenzoyl)-1,2,3,6-tetrahydrobenzoic acid (starting compound A8), 55 mmol of piperidin-4-yl-hydrazine dihydrochloride and 100 mmol of triethylamine in 150 ml of 1-propanol is refluxed for 18 h. After cooling to RT, the precipitate is filtered off and dried. M.p. 285-288° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07531540B2 |
| Source dataset | uspto-grants-2009_05 |
| ORD ID | ord-3e7ab68a8eb54c8c9af990e155f5c890 |
| Source note | uspto-grants-2009_05 |