Dimethyl 2-(5-methoxy-2-nitrophenyl)malonate → HCID 68981613, compound

HRID 491468Notes

Reaction equation

HRID 491468 reaction equation
[CH3:1][O:2][C:3](=[O:20])[CH:4]([C:9]1[CH:14]=[C:13]([O:15][CH3:16])[CH:12]=[CH:11][C:10]=1[N+:17]([O-])=O)[C:5](OC)=[O:6]>[Pd].CO>[CH3:1][O:2][C:3]([CH:4]1[C:9]2[C:10](=[CH:11][CH:12]=[C:13]([O:15][CH3:16])[CH:14]=2)[NH:17][C:5]1=[O:6])=[O:20]

Participants

4

Reactant 1

HCID 68979054Dimethyl 2-(5-methoxy-2-nitrophenyl)malonate

Product 1

HCID 68981613HCID 68981613, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

To 2-(5-methoxy-2-nitro-phenyl)-malonic acid dimethyl ester and 5% Pd—C (7.0 g) in 1 l of flask, MeOH (490 ml) is added at ambient temperature. The reaction mixture is stirred under H2 at room temperature for 15 h. The catalysts are removed by filtration and MeOH is evaporated down to give crude 5-methoxy-2-oxo-2,3-dihydro-1H-indole-3-carboxylic acid methyl ester.

Workup

  1. customThe catalysts are removed by filtration and MeOH
  2. customis evaporated down

Sources & evidence

ORD record
ord-efdf66a15f044ce79e9032a0033b2828
Source dataset
uspto-grants-2009_05
Patent number
US07531546B2

Reaction notes

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