反应详情

To a solution of 1-benzyl-piperidin-4-one (75.1 g, 0.40 mol) in toluene (400 ml), cyano-acetic acid ethyl ester (50.6 ml, 0.48 mol) and acetic acid (18.2 ml, 0.32 mol) are added at ambient temperature. The reaction mixture is refluxed for 4 h, quenched with ice-water and extracted with diethyl ether. The combined extracts are washed with H2O, brine and dried over sodium sulphate to give (1-benzyl-piperidin-4-ylidene)-cyano-acetic acid ethyl ester in quantitative yield.

1. temperatureThe reaction mixture is refluxed for 4 h
2. customquenched with ice-water
3. extractionextracted with diethyl ether
4. washThe combined extracts are washed with H2O, brine
5. dry with materialdried over sodium sulphate