Potassium Carbonate → HCID 57678383, compound

Participants

Reaction Steps

6-Bromomethyl-7-(2,2-dimethyl-propyl)-7H-pyrrolo[2,3-d]pyrimidine-2-carbonitrile (1.0 g, 3.25 mmol) and 1,3-dioxo-2,8-diaza-spiro[4.5]decane-8-carboxylic acid tert-butyl ester (0.82 g, 3.42 mmol) are dissolved in DMF (15 ml) and potassium carbonate (0.58 g, 4.23 mmol) is added to the solution. The reaction mixture is stirred at room temperature for 15 h and quenched with saturated ammonium chloride and extracted with ethyl acetate. The combined extracts are washed with H2O, brine and dried over magnesium sulfate. Chromatography on silica gel (eluent; n-hexane:ethyl acetate=2:1) gives 1.56 g of desired 2-[2-cyano-7-(2,2-dimethyl-propyl)-7H-pyrrolo[2,3-d]pyrimidin-6-ylmethyl]-1,3-dioxo-2,8-diaza-spiro[4.5]decane-8-carboxylic acid tert-butyl ester in 97% yield.

Provenance & Evidence