HCID 57678383, compound → HCID 10046162, compound

Participants

Reaction Steps

To a solution of 2-[2-cyano-7-(2,2-dimethyl-propyl)-7H-pyrrolo[2,3-d]pyrimidin-6-ylmethyl]-1,3-dioxo-2,8-diaza-spiro[4.5]decane-8-carboxylic acid tert-butyl ester (1.5 g, 3.1 mmol) in dichloromethane (20 ml), TFA (5 ml) is added at 0° C. The reaction mixture is stirred at room temperature for 2 h. After removal of the solvent, saturated sodium bicarbonate is added to the residue and the mixture is extracted with dichloromethane. The combined extracts are washed with H2O, brine, dried over magnesium sulfate and concentrated under vacuum to give desired product, 7-(2,2-dimethyl-propyl)-6-(1,3-dioxo-2,8-diaza-spiro[4.5]dec-2-ylmethyl)-7H-pyrrolo[2,3-d]pyrimidine-2-carbonitrile.

Provenance & Evidence