tert-Butoxy bis(dimethylamino)methane → HCID 68839019, compound

Participants

Reaction Conditions

Reaction Steps

(2,5-Diiodo-4-methoxy-phenoxy)-acetonitrile (2.8 g, 6.75 mmol) and tert-butoxybis(dimethylamino)methane (Bredrick's reagent, 7 mL, 33.7 mmol) were combined and heated to 105° C. under nitrogen for 2 hours. The reaction mixture was cooled and concentrated under reduced pressure to yield 3.47 g of crude 2-(2,5-diiodo-4-methoxy-phenoxy)-but-2-enenitrile, which was used directly in the following step.

Provenance & Evidence