Potassium Fluoride → HCID 57678406, compound

Participants

Reaction Steps

A mixture of 5-(2-Iodo-5-trimethylsilanylethynyl-phenoxy)-pyrimidine-2,4-diamine (0.4 g, 2.36 mmol), potassium fluoride (41 mg, 7.07 mmol) and HBr (2 drops of 48% aqueous solution) in DMF was stirred at room temperature for 30 minutes. The reaction mixture was diluted with water and EtOAc and basified with 1 mL NH4OH. The organic layer was separated, washed with water and brine, dried over MgSO4, filtered and concentrated under reduced pressure. The residue was chromatographed on silica (4% MeOH in CH2Cl2 with 0.1% NH4OH) to give 0.36 g of 5-(5-Ethynyl-2-iodo-phenoxy)-pyrimidine-2,4-diamine, MP=156-159° C., MS (M+H)=352.

Provenance & Evidence