反应详情

Ethyl 6-(2,3-dichlorobenzyl)-1,4-dihydro-8-fluoro-1-[2-(tert-butyldimethylsilyloxy)ethyl]-4-oxo-3-quinolinecarboxylate (350 mg, 0.63 mmol) obtained in Step 5 was dissolved in THF (25 ml), tetrabutylammonium fluoride (1M THF solution; 1.9 ml, 1.9 mmol) was added, and the mixture was stirred at room temperature for 1 hr. Water was added to the reaction mixture, the precipitated solid was collected by filtration, which was washed with water and vacuum dried to give the object product (279 mg, yield quantitative) as a pale-yellow solid.

1. filtrationthe precipitated solid was collected by filtration, which
2. washwas washed with water and vacuum
3. customdried
4. customto give
5. customthe object product (279 mg, yield quantitative) as a pale-yellow solid