HuagongsheHuagongshe Chemistry Print Report · For research reference only
5-Decene → 5-[4-(4-Aminomethyl-phenoxy)-phenoxy]-5-(2-ethoxy-ethyl)-pyrimidine-2,4,6-trione
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 5-Decene | HCID 23916 | — |
| Reactant | 4,4',5,5,5',5'-Hexafluoro-2,2,2',2'-tetrakis(trifluoromethyl)-4,4'-bi-1,3-dioxolane | HCID 197408 | — |
| Reactant | 4-(4-Aminomethyl-phenoxy)-phenol | HCID 20636236 | — |
| Reactant | 5-Bromo-5-(2-ethoxy-ethyl)-pyrimidine-2,4,6-trione | HCID 21931123 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Product | 5-[4-(4-Aminomethyl-phenoxy)-phenoxy]-5-(2-ethoxy-ethyl)-pyrimidine-2,4,6-trione | HCID 20636172 | 18.1% |
Reaction Steps
Following the procedure outlined for the preparation of Example 1, 4-(4-aminomethyl-phenoxy)-phenol (0.70 g, 3.32 mmol) was reacted with 5-bromo-5-(2-ethoxy-ethyl)-pyrimidine-2,4,6-trione (0.95 g, 2.4 mmol), 1,5,7-trazabicyclo[4.4.0]dec-5-ene bound to polystyrene crosslinked with 2% DVB (PTBD, Fluka, 2.22 9) and 11 mL of acetonitrile, affording 5-[4-(4-aminomethyl-phenoxy)-phenoxy]-5-(2-ethoxy-ethyl)-pyrimidine-2,4,6-trione (0.180 g) as a colorless solid after purification by reverse phase HPLC.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06706723B2 |
| Source dataset | uspto-grants-2004_03 |
| ORD ID | ord-9773a3e6fb4449d6ab49be98cb635123 |
| Source note | uspto-grants-2004_03 |