Potassium Hydroxide → HCID 67215220, compound

Participants

Reaction Steps

To a solution of 2-methyl-2H-1,2,3-triazole-4,5-dicarboxylic acid dimethylester (1.2 g; 6 mmol) in 30 ml methanol was added 358 mg KOH (assay 86%; 5.5 mmol). The mixture was heated at reflux temperature for 48 hours. The solvent was evaporated and the residue was then taken into water and extracted with ethyl acetate (3 times). The combined organic phases contained non-reacted starting material. The aqueous phase was acidified with 2N HCl (pH2-3) and extracted with ethyl acetate (3 times). The extracts were combined, dried (anhydrous MgSO4) and evaporated to dryness to give 803 mg (72%) of the desired compound (m.p. 125-126° C.; 1H-NMR (300 MHz, DMSO-d6), δ(ppm): 13.7(br.s,1H, exchangable with D2O), 4.24(s,3H), 3.84(s,3H).

Provenance & Evidence