反应详情

1-Methyl-2-(3-nitro-5-trifluoromethyl-phenoxymethyl)-pyrrolidine (2.5 g, 8.2 mmol) was dissolved in MeOH (80 ml) and HOAc (glacial, 10 mL) and placed under N2. Pd/C was added and after blanketing with H2, the mixture was shaken under H2 for 18 h at 60 psi. The catalyst was removed by filtration through Celite® and the MeOH solution was concentrated in vacuo. The residue was purified with flash chromatography (SiO2, 90:10:1 CH2Cl2:MeOH:NH4OH) to afford the title compound as a yellow liquid.

1. customThe catalyst was removed by filtration through Celite®
2. concentrationthe MeOH solution was concentrated in vacuo
3. customThe residue was purified with flash chromatography (SiO2, 90:10:1 CH2Cl2:MeOH:NH4OH)