Formaldehyde → HCID 69021578, compound

Participants

Reaction Steps

4-(2-Chloro-5-nitro-phenoxymethyl)-piperidine (4 g, 14.8 mmol) was dissolved in CH3CN (20 ml), and formaldehyde (5.9 ml, 37% aqueous) and NaBH3CN (1.49 g, 23.68 mmol) were added. After 4 h, the mixture was concentrated in vacuo and the residue was dissolved in EtOAc, washed with brine. The EtOAc portion was dried with Na2SO4, and evaporated. The title compound was purified by column chromatography using 0-75% of a 90:10:1 (CH2Cl2:MeOH: NH4OH) solution as the eluent to yield a yellow solid. MS(MH+)=NA; Calc'd 284.09 for C13H17ClN2O3.

Provenance & Evidence