1-Chloro-2-[(2-chloroethyl)oxy]-4-nitrobenzene → 4-Chloro-3-[(2-chloroethyl)oxy]aniline

Participants

Reaction Steps

To an argon-degassed solution of 1-chloro-2-(2-chloro-ethoxy)-4-nitro-benzene (2.9 g, <12.5 mmol due to contamination) in EtOAc (50 mL) was added 10% by weight Pd/C (1 g). The reaction was stirred under H2 for 18 h then filtered through Celite® and concentrated in vacuo to yield the title compound contaminated by the bromo adduct. MS (MH+)=206.1; Calc'd 206.07 for C8H9Cl2NO.

Provenance & Evidence