Nitric Acid → HCID 10313539, compound

HRID 491637Notes

Reaction equation

HRID 491637 reaction equation
[N+:1]([O-:4])([OH:3])=O.[CH3:5][C:6]1[CH:11]=[CH:10][C:9]([N+:12]([O-:14])=[O:13])=[CH:8][C:7]=1[OH:15]>O>[CH3:5][C:6]1[CH:11]=[C:10]([N+:1]([O-:4])=[O:3])[C:9]([N+:12]([O-:14])=[O:13])=[CH:8][C:7]=1[OH:15]

Participants

4

Reactant 2

HCID 944Nitric AcidHCID 935762-Methyl-5-nitrophenol

Product 1

HCID 10313539HCID 10313539, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent2×

Procedure

A solution of HNO3 (27 mL, 70% solution) and H2O (14 mL) was cooled using an ice bath and 2-methyl-5-nitrophenol (10 g, 65 mmol) was added slowly, followed by NaNO3 (90 mg, 1.3 mmol). The reaction was stirred and warmed to RT. After 4 h, H2O was added and the reaction was filtered to collect a yellow solid. This yellow solid was purified by titration with CH2Cl2 to yield the title compound as a solid that is 98% the desired isomer.

Workup

  1. filtrationthe reaction was filtered
  2. customto collect a yellow solid
  3. customThis yellow solid was purified by titration with CH2Cl2

Sources & evidence

ORD record
ord-6c344150e5c84cbea716c374932b7bc0
Source dataset
uspto-grants-2009_05
Patent number
US07531553B2

Reaction notes

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