反应详情

4-Chloroquinoline (4.3 g, 26.3 mmol) and 3,4-dinitrophenol (41.5 g, 24.4 mmol) were heated at 150° C. for 30 min. The mixture was cooled to RT and the residue was dissolved in CH2Cl2. The mixture was diluted in NaOH 2 M and extracted with CH2Cl2. The organic phase was dried, filtered and evaporated. The residue was diluted in EtOAc and filtered through a silica pad. The solvent was removed to give the title compound as a brown solid.

1. extractionextracted with CH2Cl2
2. customThe organic phase was dried
3. filtrationfiltered
4. customevaporated
5. additionThe residue was diluted in EtOAc
6. filtrationfiltered through a silica pad
7. customThe solvent was removed