1,8,8-Trimethyl-3-oxabicyclo[3.2.1]octane-2,4-dione → Racemic 3-(4-[4-(2-Pyrimidinyl)-1-piperazinyl]butyl)-1,8, 8-trimethyl-3-azabicyclo[3.2.1]octan-2,4-dione

Participants

Reaction Steps

The title compound was prepared from 2.47 g (10.4 mmol) of 1-(4-aminobutyl)-4-(2-pyrimidinyl)piperazine and 1.89 g (10.3 mmol) of dl-camphoric anhydride, substantially according to the procedure of Example 1. This afforded 0.7 g of product, mp 94°-97° C. (17% yield).

Provenance & Evidence