Ethyl 2-(3,4-difluorophenyl)-2-oxoacetate → Ethyl 3,3',4,4'-tetrafluorobenzilate

Participants

Reaction Conditions

Reaction Steps

The Grignard reagent is prepared from 2.24 g (0.092 mol) of magnesium chips, a few granules of iodine and 17.80 g (0.092 mol) of 1-bromo-3,4-difluoro-benzene in 100 ml of THF at 50° C. After the halide has all been added, the mixture is stirred for another hour. The Grignard reagent thus obtained is added dropwise to 18.81 g (0.088 mol) of ethyl 3,4-difluorophenylglyoxylate in 80 ml of THF at 10°-15° C. and the mixture obtained is stirred for 2 hours at 5° C.

Provenance & Evidence