HuagongsheHuagongshe Chemistry Print Report · For research reference only
Allyltributylstannane → 7-Allyl-2-(3-fluoro-4-hydroxyphenyl)benzo[d]oxazol-5-ol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Allyltributylstannane | HCID 90628 | — |
| Reactant | 7-Bromo-2-(3-fluoro-4-methoxyphenyl)-5-methoxy-1,3-benzoxazole | HCID 11428101 | — |
| Product | 7-Allyl-2-(3-fluoro-4-hydroxyphenyl)benzo[d]oxazol-5-ol | HCID 135502641 | — |
Reaction Steps
The title compound was prepared in substantially the same manner as described in Example 24, Route c, step b, from 7-bromo-2-(3-fluoro-4-methoxyphenyl)-5-methoxy-1,3-benzoxazole, allyltributyltin and dichlorobis(trio-tolylphosphine)palladium, followed by demethylation according to Example 20, step e. The desired product was obtained as a light pink solid, m.p. 169-171° C.; MS m/e 284 (M−H)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07531564B2 |
| Source dataset | uspto-grants-2009_05 |
| ORD ID | ord-c2d1f1bafa07458e8bbfb87272eec826 |
| Source note | uspto-grants-2009_05 |