Boron tribromide → HCID 135483639, compound

HRID 491748Notes

Reaction equation

HRID 491748 reaction equation
C[O:2][C:3]1[CH:4]=[C:5]([CH2:20]O)[C:6]2[O:10][C:9]([C:11]3[CH:16]=[CH:15][C:14]([O:17]C)=[CH:13][CH:12]=3)=[N:8][C:7]=2[CH:19]=1.B(Br)(Br)[Br:23]>>[Br:23][CH2:20][C:5]1[C:6]2[O:10][C:9]([C:11]3[CH:16]=[CH:15][C:14]([OH:17])=[CH:13][CH:12]=3)=[N:8][C:7]=2[CH:19]=[C:3]([OH:2])[CH:4]=1

Participants

3

Reactant 2

HCID 25134Boron tribromideHCID 21907364HCID 21907364, compound

Product 1

HCID 135483639HCID 135483639, compound

Procedure

The title compound was prepared according to the procedure of Example 20, step e (Route b), from 5-methoxy-7-(hydroxymethyl)-2-(4-methoxyphenyl)-1,3-benzoxazole with prolonged stirring in the presence of boron tribromide, and was obtained as a light brown solid, m.p. 250-260° C. (dec); MS m/e 321 (M+H)+.

Workup

  1. customwas obtained as a light brown solid, m.p. 250-260° C. (dec)

Sources & evidence

ORD record
ord-1fc32ac6091149ec96ab8eb636ecb83f
Source dataset
uspto-grants-2009_05
Patent number
US07531564B2

Reaction notes

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