Sodium Hydroxide → HCID 178524190, compound

Participants

Reaction Steps

Trans-5-methoxycarbonyl-3-[4-(2-oxopyrrolidin-1-yl)-cyclohexylcarbonylamino]-N-(5-chloropyridin-2-yl)benzofuran-2-carboxamide (710 mg) obtained in Example 1 is suspended in tetrahydrofuran-methanol (1:1, 10 ml), and thereto is added 4N aqueous sodium hydroxide solution (2 ml) under ice-cooling. The mixture is warmed to room temperature, and stirred for 18 hours. The reaction solution is concentrated under reduced pressure, and thereto is poured ice-water, and the mixture is neutralized with 10% hydrochloric acid. The precipitates are collected by filtration, washed with water, and dried to give the title compound (655 mg).

Provenance & Evidence