Sodium Hydroxide → HCID 178485735, compound

Participants

Reaction Steps

Trans-3-[4-(N-formyl-N-methylamino)cyclohexylcarbonylamino]-5-methoxycarbonyl-N-(5-chloropyridin-2-yl)benzofuran-2-carboxamide (1.90 g) obtained in Example 234 is suspended in tetrahydrofuran/methanol (1:1, 50 ml), and thereto is added 4N aqueous sodium hydroxide solution (5 ml) under ice-cooling. The mixture is warmed to room temperature, and stirred for 17 hours. The reaction solution is concentrated under reduced pressure, and to the residue is poured ice-water, and the mixture is neutralized with 10% hydrochloric acid. The precipitates are collected by filtration, washed successively with water and tetrahydrofuran, and dried to give the title compound (1.59 g).

Provenance & Evidence