反应详情

3-((Piperidin-4-yl)carbonylamino)-N-(5-chloropyridin-2-yl)benzofuran-2-carboxamide (100 mg) obtained in Example 228 is suspended in N,N-dimethylacetamide (3 ml), and thereto are added 4-(chloromethyl)pyridine hydrochloride (45 mg), sodium carbonate (80 mg) and sodium iodide (41 mg), and the mixture is stirred at room temperature for 12 hours. To the reaction solution is poured a saturated aqueous sodium hydrogen carbonate solution, and the mixture is extracted with ethyl acetate. The organic layer is washed with water and a saturated brine, and dried over sodium sulfate. The solvent is evaporated under reduced pressure, and the resulting residue is purified by NH-silica gel column chromatography (eluent: n-hexane/ethyl acetate=2/1, then 1/1) to give the title compound (109 mg).

1. extractionthe mixture is extracted with ethyl acetate
2. washThe organic layer is washed with water
3. dry with materiala saturated brine, and dried over sodium sulfate
4. customThe solvent is evaporated under reduced pressure
5. customthe resulting residue is purified by NH-silica gel column chromatography (eluent