Methyl iodide → HCID 86602242, compound

HRID 491802Notes

Reaction equation

HRID 491802 reaction equation
[CH3:1][N:2]([CH3:31])[C@H:3]1[CH2:8][CH2:7][C@H:6]([C:9]([NH:11][C:12]2[C:16]3[CH:17]=[CH:18][CH:19]=[CH:20][C:15]=3[O:14][C:13]=2[C:21]([NH:23][C:24]2[CH:29]=[CH:28][C:27]([Cl:30])=[CH:26][N:25]=2)=[O:22])=[O:10])[CH2:5][CH2:4]1.[CH3:32][I:33]>>[I-:33].[Cl:30][C:27]1[CH:28]=[CH:29][C:24]([NH:23][C:21]([C:13]2[O:14][C:15]3[CH:20]=[CH:19][CH:18]=[CH:17][C:16]=3[C:12]=2[NH:11][C:9]([CH:6]2[CH2:5][CH2:4][CH:3]([N+:2]([CH3:32])([CH3:31])[CH3:1])[CH2:8][CH2:7]2)=[O:10])=[O:22])=[N:25][CH:26]=1

Participants

3

Reactant 2

HCID 6328Methyl iodideHCID 178484069HCID 178484069, compound

Product 1

HCID 86602242HCID 86602242, compound

Procedure

Trans-3-[4-(dimethylamino)cyclohexylcarbonylamino]-N-(5-chloropyridin-2-yl)benzofuran-2-carboxamide (150 mg) obtained in Example 306 and methyl iodide (21 μl) are treated in a similar manner to Example 367 to give the title compound (137 mg).

Sources & evidence

ORD record
ord-f772caf0172f4536b9f92bca4c557183
Source dataset
uspto-grants-2009_05
Patent number
US07531537B2

Reaction notes

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