2-Chloropyrimidine → HCID 178478891, compound

HRID 491804Notes

Reaction equation

HRID 491804 reaction equation
Cl.Cl.[NH2:3][C@H:4]1[CH2:9][CH2:8][C@H:7]([C:10]([NH:12][C:13]2[C:17]3[CH:18]=[CH:19][CH:20]=[CH:21][C:16]=3[O:15][C:14]=2[C:22]([NH:24][C:25]2[CH:30]=[CH:29][C:28]([Cl:31])=[CH:27][N:26]=2)=[O:23])=[O:11])[CH2:6][CH2:5]1.[Cl:32][C:33]1[N:38]=[CH:37][CH:36]=[CH:35][N:34]=1>>[ClH:31].[ClH:32].[N:34]1[CH:35]=[CH:36][CH:37]=[N:38][C:33]=1[NH:3][C@H:4]1[CH2:9][CH2:8][C@H:7]([C:10]([NH:12][C:13]2[C:17]3[CH:18]=[CH:19][CH:20]=[CH:21][C:16]=3[O:15][C:14]=2[C:22]([NH:24][C:25]2[CH:30]=[CH:29][C:28]([Cl:31])=[CH:27][N:26]=2)=[O:23])=[O:11])[CH2:6][CH2:5]1

Participants

3

Reactant 2

HCID 744042-ChloropyrimidineHCID 178478721HCID 178478721, compound

Product 1

HCID 178478891HCID 178478891, compoundYield 32%

Procedure

Trans-3-[4-aminocyclohexylcarbonylamino]-N-(5-chloropyridin-2-yl)benzofuran-2-carboxamide dihydrochloride (350 mg) obtained in Example 219 and 2-chloropyrimidine (99 mg) are treated in a similar manner to Example 373 to give the title compound (65 mg).

Sources & evidence

ORD record
ord-8c5abff16688472d94ba3baec0055835
Source dataset
uspto-grants-2009_05
Patent number
US07531537B2

Reaction notes

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