Hydrochloric Acid → HCID 178484426, compound

Participants

Reaction Steps

Trans-3-[4-(N-acetoxyacetyl-N-methylamino)cyclohexylcarbonylamino]-5-dimethylaminocarbonyl-N-(5-chloropyridin-2-yl)benzofuran-2-carboxamide (91 mg) obtained in Example 398 is dissolved in tetrahydrofuran/methanol (2:3, 5 ml), and thereto is added at room temperature 2N aqueous sodium hydroxide solution (300 μl), and the mixture is stirred for 4 hours. The reaction solution is acidified with diluted hydrochloric acid, and the mixture is diluted with chloroform. The mixture is dried over sodium sulfate, and the solvent is evaporated under reduced pressure. The resulting residue is purified by recycle HPLC to give the title compound (44 mg).

Provenance & Evidence