Hydrochloric Acid → HCID 11611928, compound

Participants

Reaction Conditions

Reaction Steps

[5-Bromo-1-(4-methoxy-benzenesulfonyl)-1H-indol-3-yloxy]-acetic acid methyl ester (22, 32.0 mg, 0.007 mmol) was dissolved in THF (1.50 mL) and 1M lithium hydroxide (0.4 mL) was added to this solution. After stirring for 30 min at 25° C., ethyl acetate was added and the mixture was acidified with 1M hydrochloric acid. The organic layer was dried over magnesium sulfate, filtered and concentrated at reduced pressure to obtain a white solid (23, 28 mg, 90% yield). MS(ESI) [M−H+]−=438.0; 440.0.

Provenance & Evidence