Benzenesulfonyl chloride, 3,4-dichloro- → HCID 57678944, compound

Participants

Reaction Steps

To a dry round bottom flask, (5-Methoxy-1H-indol-3-ylsulfanyl)-acetic acid methyl ester (25, 7.0 mg, 0.027 mmol) was dissolved with CH2Cl2 (3.0 mL). Tetrabutylammonium hydrogen sulfate (2.0 mg) and 50% KOH solution (3.0 mL) were added next. After about 5 minutes of stirring, 3,4-dichloro-benzenesulfonyl chloride (20 mg, 0.081 mmol) was added. This reaction was allowed to stir at ambient temperature overnight. The reaction was extracted with dichloromethane (2×14 mL), washed with water (5 mL), brine (5 mL) and dried over anhydrous magnesium sulfate. The reactant was filtered and rotoevaporated to give the desired product 26 as off white solid.

Provenance & Evidence