Sodium borohydride → HCID 57678374, compound

Participants

Reaction Steps

To a solution of 2-[4-(2-amino-6-phenoxy-4H-quinazolin-3-yl)-4-cyclohexyl-butyrylamino]-3-tert-butoxy-propionic acid methyl ester (TFA salt, 50 mg) in methanol (5 mL), NaBH4 (0.04 g) was added slowly over a 30 minute period. The resulting solution was then stirred at room temperature overnight. LC/MS indicated very little product formed and most of the starting material remained. Additional NaBH4 (0.04 g) was added at room temperature, and the solution was stirred for an additional 8 hrs. Additional NaBH4 (0.08 g) was added over a 4 day period. LC/MS then indicated that most of the starting material was converted. The crude reaction mixture was purified by Gilson HPLC to yield the title compound as a white solid.

Provenance & Evidence