huagongshe.com
HRID491883

反应详情

EQUATION

反应方程式

HRID 491883 的结构方程式

REACTANTS

反应物

1
结构：NC1=Nc2cnc(Oc3ccccc3)cc2CN1[C@@H](CCC(=O)N(CCOCc1ccccc1)C1CCC(C(=O)OCc2ccccc2)CC1)C1CCOCC1
HCID67023458

未命名化合物

PRODUCTS

生成物

1
结构：NC1=Nc2cnc(Oc3ccccc3)cc2CN1[C@@H](CCC(=O)N(CCOCc1ccccc1)[C@H]1CC[C@@H](C(=O)O)CC1)C1CCOCC1
HCID178508228

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

2
结构：[Pd]
催化剂HCID23938

Palladium

Pd

结构：CCO
溶剂HCID702

Ethanol

C2H6O

PROCEDURE

实验过程

A solution of 4-[[4-(2-Amino-6-phenoxy-4H-pyrido[3,4-d]pyrimidin-3-yl)-4-(S)-(tetrahydro-pyran-4-yl)-butyryl]-(2-benzyloxy-ethyl)-amino]-cyclohexanecarboxylic acid benzyl ester (0.4 g, 0.42 mmol) and Pd (10% on carbon, 0.2 g) in EtOH (50 mL) was subjected to hydrogenation under 10 psi for 48 h. HPLC purification yielded 4-[[4-(2-Amino-6-phenoxy-4H-pyrido[3,4-d]pyrimidin-3-yl)-4-(S-(tetrahydro-pyran-4-yl)-butyryl]-(2-hydroxy-ethyl)-amino]-cyclohexanecarboxylic acid as a white solid and 4-[[4-(2-Amino-6-phenoxy-4H-pyrido[3,4-d]pyrimidin-3-yl)-4-(S)-(tetrahydro-pyran-4-yl)-butyryl]-(2-benzyloxy-ethyl)-amino]-cis-cyclohexanecarboxylic acid as a white solid.

WORKUP

后处理

  1. customHPLC purification