Dimethylformamide → HCID 67023487, compound

Participants

Reaction Steps

To a stirred solution of 4-tert-butoxycarbonylamino-4-(S)-cyclohexyl-butyric acid (2.63 g, 9.2 mmole) were added (1-benzyl-1H-tetrazol-5-ylmethyl)-cyclohexyl-amine (2.50 g, 9.2 mmole) and N,N-diisopropylethylamine (3.2 mL, 18.4 mmole) in DMF (50 mL) and HBTU (4.19 g, 11.0 mmole). After stirring at room temperature overnight, the reaction mixture was diluted with diethyl ether (200 mL). The reaction mixture was extracted with water three times and dried over magnesium sulfate. The solution was concentrated to yield {3-[(1-benzyl-1H-tetrazol-5-ylmethyl)-cyclohexyl-carbamoyl]-(S)-cyclohexyl-propyl}-carbamic acid as a colorless oil.

Provenance & Evidence