HCID 67023507, compound → HCID 67023482, compound

Participants

Reaction Steps

To a solution of N-(1-(R)-tert-butoxymethyl-2-morpholin-4-yl-2-oxo-ethyl)-4-(S)-cyclohexyl-4-[(5-nitro-2-phenoxy-pyridin-4-ylmethyl)-amino]-butyramide (0.4 g, 0.6 mmol) in MeOH (10 mL) was added 10% Pd on activated carbon (0.1 g) under N2. The reaction mixture was subjected to hydrogenation under 5 psi for 2 h. The catalyst was filtered out, and the MeOH was evaporated to yield 4-[(5-amino-2-phenoxy-pyridin-4-ylmethyl)-amino]-N-(1-(R)-tert-butoxymethyl-2-morpholin-4-yl-2-oxo-ethyl)-4-(S)-cyclohexyl-butyramide as an oil.

Provenance & Evidence