Cyanogen Bromide → HCID 57678340, compound

Participants

Reaction Steps

A solution of 4-[(5-amino-2-phenoxy-pyridin-4-ylmethyl)-amino]-N-(1-(R)-tert-butoxymethyl-2-morpholin-4-yl-2-oxo-ethyl)-4-(S)-cyclohexyl-butyramide (0.37 g, 0.6 mmol) and BrCN (3M in CH2Cl2, 0.25 mL) in EtOH (20 mL) was stirred at room temperature overnight. The EtOH was evaporated to yield an oil, which was purified by Gilson HPLC to yield 4-(2-amino-6-phenoxy-4H-pyrido[3,4-d]pyrimidin-3-yl)-N-(1-(R)-tert-butoxymethyl-2-morpholin-4-yl-2-oxo-ethyl)-4-(S)-cyclohexyl-butyramide as a white solid, as its corresponding TFA salt.

Provenance & Evidence