HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 1-benzyl-1H-[1,2,4]triazole-3-carboxylic acid cyclohexylamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Cyclohexylamine | HCID 7965 | — |
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | Methanaminium, N-((1H-benzotriazol-1-yloxy)(dimethylamino)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1) | HCID 2733084 | — |
| Reactant | 1-Benzyl-1H-1,2,4-triazole-3-carboxylic acid | HCID 15707919 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 1-benzyl-1H-[1,2,4]triazole-3-carboxylic acid cyclohexylamide | HCID 67023585 | — |
Reaction Steps
To a stirred solution of 1-benzyl-1H-[1,2,4]triazole-3-carboxylic acid (1.54 g, 7.6 mmol), cyclohexylamine (0.87 mL, 7.6 mmol) and N,N-diisopropylethylamine (2.65 mL, 15.1 mmol) in DMF (30 mL) was added HBTU (3.45 g, 9.1 mmol). The solution was then stirred at room temperature overnight. Aqueous hydrochloric acid was added and the solution was filtered to yield 1-benzyl-1H-[1,2,4]triazole-3-carboxylic acid cyclohexylamide as a white solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07531545B2 |
| Source dataset | uspto-grants-2009_05 |
| ORD ID | ord-aa2e6891a99c492dafa40db9546ccacb |
| Source note | uspto-grants-2009_05 |