Methanol → 3-Amino-3-cyclohexyl-N-(3,3-dimethyl-butyl)-propionamide

Participants

Reaction Steps

In a Parr bottle 10% Pd/C (0.8 g) was cooled to −78° C., followed by addition of a solution of 3-[benzyl-(1-phenyl-ethyl)-amino]-3-cyclohexyl-N-(3,3-dimethyl-butyl)-propionamide (0.8 g, 1.78 mmol) in ethyl acetate (10 mL), ethanol (100 mL), and methanol (20 mL). The resulting mixture was subjected to hydrogen atmosphere and shaken for 3 h. The hydrogen was purged with nitrogen, the reaction mixture was filtered (glass fiber filter paper) and the solvent was evaporated under reduced pressure to yield a residue.

Provenance & Evidence