Sodium Methoxide → HCID 178426010, compound

HRID 49193Notes

Reaction equation

HRID 49193 reaction equation
Cl.[F:2][C:3]1[CH:4]=[CH:5][C:6]([CH3:25])=[C:7]([CH:9]2[CH2:18][C:17]3[N:16]=[CH:15][CH:14]=[C:13]([CH3:19])[C:12]=3[C:11](=[N:20][NH:21][C:22]([NH2:24])=[NH:23])[CH2:10]2)[CH:8]=1.C[O-].[Na+]>CO>[F:2][C:3]1[CH:4]=[CH:5][C:6]([CH3:25])=[C:7]([CH:9]2[CH2:18][C:17]3[N:16]=[CH:15][CH:14]=[C:13]([CH3:19])[C:12]=3[C:11](=[N:20][NH:21][C:22]([NH2:24])=[NH:23])[CH2:10]2)[CH:8]=1

Participants

4

Reactant 2

HCID 10942334Sodium MethoxideHCID 178426011HCID 178426011, compound

Product 1

HCID 178426010HCID 178426010, compoundYield 83.8%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent2×

Procedure

(±)-7-(5-Fluoro-2-methylphenyl)-5-guanidinoimino-4-methyl-5,6,7,8-tetrahydroquinoline hydrochloride (43.8 g) was suspended in methanol (300 ml), and treated dropwise with a 28% solution of sodium methoxide in methanol (53.1 g). The mixture was concentrated under reduced pressure, and the residue was washed with water and dried to obtain (±)-7-(5-fluoro-2-methylphenyl)-5-guanidinoimino-4-methyl-5,6,7,8-tetrahydroquinoline (33.0 g).

Workup

  1. concentrationThe mixture was concentrated under reduced pressure
  2. washthe residue was washed with water
  3. customdried

Sources & evidence

ORD record
ord-a8150fe1ffa94cbc8ea45b5f740e3676
Source dataset
uspto-grants-2004_03
Patent number
US06706732B1

Reaction notes

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