反应详情

Sodium hydroxide (0.78 g) was dissolved in water (55 ml) and treated dropwise with acetone (55 ml) followed by a solution of 2-chloro-5-fluorobenzaldehyde (2.8 g) in acetone (10 ml). The reaction mixture was stirred at room temperature for 2 hours. Acetone was distilled off under reduced pressure, and the residue was extracted with ethyl acetate. The organic layer was washed successively with water and saturated brine, and concentrated under reduced 5 pressure to obtain 4-(2-chloro-5-fluorophenyl)-3-buten-2-one (0.24 g).

1. distillationAcetone was distilled off under reduced pressure
2. extractionthe residue was extracted with ethyl acetate
3. washThe organic layer was washed successively with water and saturated brine
4. concentrationconcentrated under reduced 5 pressure