Toluene → (2S)-2-[(1H-imidazole-2-carbonyl)-amino]-propionic acid

Participants

Reaction Steps

A solution of (2S)-2-[(1H-imidazole-2-carbonyl)-amino]-propionic acid tert-butyl ester (0.257 g) in dichloromethane (2 ml) was cooled to 0° C. before dropwise addition of trifluoroacetic acid and the reaction mixture was warmed to room temperature and stirred for 2 hr before evaporation under reduced pressure. The residue was co-evaporated with dichloromethane (twice) and toluene (twice) to leave the required (2S)-2-[(1H-imidazole-2-carbonyl)-amino]-propionic acid that was used without further purification (0.40 g).

Provenance & Evidence