HCID 21867349, compound → HCID 14518958, compound

HRID 491980Notes

Reaction equation

HRID 491980 reaction equation
[CH3:1][NH:2][C:3](=[O:18])[CH2:4][N:5]([CH2:13][C:14]([NH:16][CH3:17])=[O:15])CC1C=CC=CC=1>CO.[Pd]>[CH3:17][NH:16][C:14](=[O:15])[CH2:13][NH:5][CH2:4][C:3]([NH:2][CH3:1])=[O:18]

Participants

4

Reactant 1

HCID 21867349HCID 21867349, compound

Product 1

HCID 14518958HCID 14518958, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Conditions

Temperature
40 °C

Procedure

The mixture of N-(2-methylamino-2-oxoethyl)-N-(phenylmethyl)-glycine methylamide (3.09 g, 11.2 mmol) in MeOH (30 mL) was added 10% Pd/C (0.15 g). The mixture was stirred and heated to 40° C. under 40 psi H2 for 10 h, filtered and concentrated in vacuo to yield N-(2-methylamino-2-oxoethyl)-glycine methylamide in quantitative yield (1.76 g). 1H NMR (CDCl3): δ 6.95 (br s, 2H), 3.23 (s, 4H), 2.79 (d, J=6.0, 4.8 Hz), 2.25 (br s 1H); MS (ESI) m/e 160 (M+H+)

Workup

  1. filtrationfiltered
  2. concentrationconcentrated in vacuo

Sources & evidence

ORD record
ord-ae480de714cb48fda70d4bcd3524d6b1
Source dataset
uspto-grants-2009_05
Patent number
US07531566B2

Reaction notes

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