Sodium Methoxide → HCID 178428132, compound

HRID 49199Notes

Reaction equation

HRID 49199 reaction equation
Cl.[Cl:2][C:3]1[CH:8]=[CH:7][C:6]([F:9])=[CH:5][C:4]=1[CH:10]1[CH2:19][C:18]2[N:17]=[CH:16][CH:15]=[C:14]([CH3:20])[C:13]=2[C:12](=[N:21][NH:22][C:23]([NH2:25])=[NH:24])[CH2:11]1.C[O-].[Na+]>CO>[Cl:2][C:3]1[CH:8]=[CH:7][C:6]([F:9])=[CH:5][C:4]=1[CH:10]1[CH2:19][C:18]2[N:17]=[CH:16][CH:15]=[C:14]([CH3:20])[C:13]=2[C:12](=[N:21][NH:22][C:23]([NH2:25])=[NH:24])[CH2:11]1

Participants

4

Reactant 2

HCID 10942334Sodium MethoxideHCID 178428133HCID 178428133, compound

Product 1

HCID 178428132HCID 178428132, compoundYield 89.2%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent2×

Procedure

(±)-7-(2-chloro-5-fluorophenyl)-5-guanidinoimino-4-methyl-5,6,7,8-tetrahydroquinoline hydrochloride (8.8 g) was suspended in methanol (100 ml) and treated dropwise with a 28% solution of sodium methoxide in methanol (8.9 g) The mixture was concentrated under reduced pressure, and the result was washed with water and dried to obtain (±)-7-(2-chloro-5-fluorophenyl)-5-guanidinoimino-4-methyl-5,6,7,8-tetrahydroquinoline (7.1 g).

Workup

  1. concentrationwas concentrated under reduced pressure
  2. washthe result was washed with water
  3. customdried

Sources & evidence

ORD record
ord-210b3f09cbc54e9e9876b058236c9357
Source dataset
uspto-grants-2004_03
Patent number
US06706732B1

Reaction notes

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