反应详情

(±)-7-(2-chloro-5-fluorophenyl)-5-guanidinoimino-4-methyl-5,6,7,8-tetrahydroquinoline hydrochloride (8.8 g) was suspended in methanol (100 ml) and treated dropwise with a 28% solution of sodium methoxide in methanol (8.9 g) The mixture was concentrated under reduced pressure, and the result was washed with water and dried to obtain (±)-7-(2-chloro-5-fluorophenyl)-5-guanidinoimino-4-methyl-5,6,7,8-tetrahydroquinoline (7.1 g).

1. concentrationwas concentrated under reduced pressure
2. washthe result was washed with water
3. customdried